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POSTNATAL DEVELOPMENT OF INNERVATION IN THE INCISIVE PAPILLA OF RAT
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±¸´ëÇÐ/Dae-Hag Koo
ÀÌÀç¹®/±èÇöÁ¤/³²¼øÇö/±è¿µÁø/Jae-Mun Lee/Hyun-Jung Kim/Soon-Hyun Nam/Young-Jin Kim
KMID : 0358919960230010035
Abstract
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Ãâ»ýÈÄ ¼ºÀå¿¡ µû¸¥ ÀýÄ¡ À¯µÎÀÇ ½Å°æºÐÆ÷ ¹× º¯È¸¦ °üÂûÇϱâ À§ÇÏ¿© »ýÈÄ 1, 5, 10, 15,
20, 25, 35ÀÏ µÈ ¹é¼¿Í ¿ÏÀüÈ÷ ¼ºÀåÇÑ ¹é¼¸¦ ´ë»óÀ¸·Î calcitonin gene related peptide
(CGRP)¸¦ ÀÌ¿ëÇÑ ¸é¿ªÁ¶Á÷ ÈÇÐÀû ¹æ¹ýÀ¸·Î °üÂûÇÏ¿© ´ÙÀ½°ú °°Àº °á°ú¸¦ ¾ò¾ú´Ù.
»ýÈÄ 1Àϱº¿¡¼´Â ¿°ÁÖ¾Ë ¸ð¾çÀÇ ±½Àº ½Å°æ¼¶À¯°¡ ¼º±ä °áÇÕÁ¶Á÷¿¡ ³ªÅ¸³µ´Ù. 5Àϱº¿¡´Â
ÀÌ·¯ÇÑ ½Å°æ¼¶À¯ÀÇ ¹Ðµµ¿Í ºÐÁö°¡ Áõ°¡ÇÏ¿© »óÇÇÇÏÃþÀ¸·Î ´õ¿í °¡±îÀÌ ¿¬ÀåµÇ¾ú°í ¿©·¯°³ÀÇ
varicositiesµµ °üÂûµÇ¾ú´Ù. 10ÀϱººÎÅÍ ½Å°æ¼¶À¯ÀÇ ºÐÁö ¹× ¹Ðµµ°¡ Áõ°¡ÇÏ¿´°í »óÇÇÇÏÃþ¿¡¼
½Å°æÃÑÀ» °üÂûÇÒ ¼ö ÀÖ¾úÀ¸¸ç »óÇdz»½Å°æ¼¶À¯ÀÇ ÁøÀÔÀ» °üÂûÇÒ ¼ö ÀÖ¾ú´Ù. 20Àϱº¿¡¼´Â Áõ
°¡µÈ »óÇÇÃþ³» ½Å°æ¼¶À¯¸¦ °üÂûÇÒ ¼ö ÀÖ¾úÀ¸³ª 25Àϱº¿¡¼ºÎÅÍ Àü¹ÝÀûÀÎ ½Å°æ¼¶À¯ÀÇ ºÐÆ÷
¹× ¹Ðµµ°¡ ¸¹ÀÌ °¨¼ÒµÇ¾úÀ¸¸ç ¼ºÀåÀÌ ¿Ï·áµÈ ±º¿¡¼´Â chemosensory corpuscle Áö¿ªÀ» Á¦
¿ÜÇÏ°í´Â ½Å°æ¼¶À¯¸¦ °ÅÀÇ °üÂûÇÒ ¼ö ¾ø¾ú´Ù.
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The purpose of this study was to investigate the distribution of nerves in the incisive
papilla of rat by each developing stage.
The distribution of nerves in the incisive papilla was investigated by means of
immunohistochemistry using an antibody against calcitonin gene related peptide (CGRP).
The results were as follows :
At 1 day after birth, CGRP-immunoreactive(IR) nerve fibers first appeared in loose
connective tissue without forming an apparent terminal structure.
At 5 days, the CGRP-IR nerve fibers increased in density and extended more to
subepithelium.
CGRP-lR nerve fiber began to penetrate into the epithelium at 10 days and reached
maximum at 20 days.
At 25 days, intraepithelial nerve fibers were not found, and the distribution and
density of nerve fiber began to decrease. In adult rat, the nerve fiber almost could not
be found in dome region except in chemosensory corpuscle region.
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